Role of stem cells in the treatment of osteoarthritis- a review of literature.
J Pak Med Assoc
; 73(Suppl 1)(2): S93-S97, 2023 Feb.
Article
in En
| MEDLINE
| ID: mdl-36788399
ABSTRACT
The purpose of this review was to identify and assess the effectiveness of stem cells in the form of injectables in the treatment of joint osteoarthritis as published in the literature. Studies were searched from multiple databases like Pubmed, Embase and Cochrane Library until June 2022 using multiple keywords. Randomized controlled trials of patients with osteoarthritis (OA) were included which compared the pain and functional outcomes for those getting Mesenchymal Stem Cells (MSCs) injectables as compared to those who received no MSCs injection. Twelve randomized controlled trials, assessing a total of 486 participants were identified and studied. Overall, stem cells injection has no significant effect on pain along with physical function. Stem cells injection could be effective in reducing pain and might also help in improving functional outcome in patients with OA. However, the findings are not yet significant and further clinical trials with larger samples are needed to come to a positive conclusion.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoarthritis, Knee
/
Mesenchymal Stem Cell Transplantation
Type of study:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
J Pak Med Assoc
Year:
2023
Document type:
Article