Chemical constituents of Ajuga forrestii and their anti-ferroptosis activity.
Fitoterapia
; 166: 105461, 2023 Apr.
Article
in En
| MEDLINE
| ID: mdl-36804655
ABSTRACT
Six new neoclerodane diterpenoids (1-6), along with ten known compounds (7-16), were isolated from Ajuga forrestii. Their structures were elucidated by HRESIMS, 1D and 2D NMR, ECD calculation, and single-crystal X-ray diffraction analysis. The structure of a known neoclerodane diterpene ajudecunoid C (6) was revised based on the reported NMR empirical rules. All the isolates were evaluated for their inhibitory effect on RSL3-induced ferroptosis in HT22 mouse hippocampal neuronal cells. Among them, compounds 8, 9, and 12 significantly inhibited RSL3-induced ferroptosis with EC50 values of 0.45 µM, 0.076 µM, and 0.14 µM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ajuga
Limits:
Animals
Language:
En
Journal:
Fitoterapia
Year:
2023
Document type:
Article