Treat-to-target recommendations in giant cell arteritis and polymyalgia rheumatica.
Ann Rheum Dis
; 83(1): 48-57, 2024 Jan 02.
Article
in En
| MEDLINE
| ID: mdl-36828585
ABSTRACT
OBJECTIVES:
To develop treat-to-target (T2T) recommendations in giant cell arteritis (GCA) and polymyalgia rheumatica (PMR).METHODS:
A systematic literature review was conducted to retrieve data on treatment targets and outcomes in GCA/PMR as well as to identify the evidence for the effectiveness of a T2T-based management approach in these diseases. Based on evidence and expert opinion, the task force (29 participants from 10 countries consisting of physicians, a healthcare professional and a patient) developed recommendations, with consensus obtained through voting. The final level of agreement was provided anonymously.RESULTS:
Five overarching principles and six-specific recommendations were formulated. Management of GCA and PMR should be based on shared decisions between patient and physician recognising the need for urgent treatment of GCA to avoid ischaemic complications, and it should aim at maximising health-related quality of life in both diseases. The treatment targets are achievement and maintenance of remission, as well as prevention of tissue ischaemia and vascular damage. Comorbidities need to be considered when assessing disease activity and selecting treatment.CONCLUSION:
These are the first T2T recommendations for GCA and PMR. Treatment targets, as well as strategies to assess, achieve and maintain these targets have been defined. The research agenda highlights the gaps in evidence and the need for future research.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymyalgia Rheumatica
/
Giant Cell Arteritis
Type of study:
Guideline
Aspects:
Patient_preference
Limits:
Humans
Language:
En
Journal:
Ann Rheum Dis
Year:
2024
Document type:
Article