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Safety of elexacaftor/tezacaftor/ivacaftor dose reduction: Mechanistic exploration through physiologically based pharmacokinetic modeling and a clinical case series.
Hong, Eunjin; Li, Regina; Shi, Alan; Almond, Lisa M; Wang, Joshua; Khudari, Amin Z; Haddad, Soumar; Sislyan, Sarkis; Angelich, Marissa; Chung, Peter S; Rao, Adupa P; Beringer, Paul M.
Affiliation
  • Hong E; Department of Clinical Pharmacy, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, California, Los Angeles, USA.
  • Li R; Department of Clinical Pharmacy, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, California, Los Angeles, USA.
  • Shi A; Department of Clinical Pharmacy, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, California, Los Angeles, USA.
  • Almond LM; Simcyp Division, Certara UK Ltd, Sheffield, UK.
  • Wang J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Khudari AZ; USC Anton Yelchin CF Clinic, Los Angeles, California, USA.
  • Haddad S; Department of Clinical Pharmacy, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, California, Los Angeles, USA.
  • Sislyan S; Department of Clinical Pharmacy, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, California, Los Angeles, USA.
  • Angelich M; Department of Clinical Pharmacy, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, California, Los Angeles, USA.
  • Chung PS; Department of Clinical Pharmacy, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, California, Los Angeles, USA.
  • Rao AP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Beringer PM; USC Anton Yelchin CF Clinic, Los Angeles, California, USA.
Pharmacotherapy ; 43(4): 291-299, 2023 04.
Article in En | MEDLINE | ID: mdl-36866442
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Cystic Fibrosis Transmembrane Conductance Regulator / Cystic Fibrosis Type of study: Prognostic_studies Limits: Adult / Humans Language: En Journal: Pharmacotherapy Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Cystic Fibrosis Transmembrane Conductance Regulator / Cystic Fibrosis Type of study: Prognostic_studies Limits: Adult / Humans Language: En Journal: Pharmacotherapy Year: 2023 Document type: Article