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Limitations of gene editing assessments in human preimplantation embryos.
Liang, Dan; Mikhalchenko, Aleksei; Ma, Hong; Marti Gutierrez, Nuria; Chen, Tailai; Lee, Yeonmi; Park, Sang-Wook; Tippner-Hedges, Rebecca; Koski, Amy; Darby, Hayley; Li, Ying; Van Dyken, Crystal; Zhao, Han; Wu, Keliang; Zhang, Jingye; Hou, Zhenzhen; So, Seongjun; Han, Jongsuk; Park, Jumi; Kim, Chong-Jai; Zong, Kai; Gong, Jianhui; Yuan, Yilin; Gu, Ying; Shen, Yue; Olson, Susan B; Yang, Hui; Battaglia, David; O'Leary, Thomas; Krieg, Sacha A; Lee, David M; Wu, Diana H; Duell, P Barton; Kaul, Sanjiv; Kim, Jin-Soo; Heitner, Stephen B; Kang, Eunju; Chen, Zi-Jiang; Amato, Paula; Mitalipov, Shoukhrat.
Affiliation
  • Liang D; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 S. Bond Avenue, Portland, OR, 97239, USA.
  • Mikhalchenko A; Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
  • Ma H; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 S. Bond Avenue, Portland, OR, 97239, USA.
  • Marti Gutierrez N; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 S. Bond Avenue, Portland, OR, 97239, USA.
  • Chen T; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 S. Bond Avenue, Portland, OR, 97239, USA.
  • Lee Y; Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250001, China.
  • Park SW; Department of Biomedical Science, College of Life Science and CHA Advanced Research Institute, CHA University, Seongnam, Gyeonggi, 13488, Republic of Korea.
  • Tippner-Hedges R; Stem Cell Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
  • Koski A; Center for Genome Engineering, Institute for Basic Science, 70, Yuseong-daero 1689-gil, Yuseong-gu, Daejeon, 34047, Republic of Korea.
  • Darby H; School of Dentistry, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
  • Li Y; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 S. Bond Avenue, Portland, OR, 97239, USA.
  • Van Dyken C; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 S. Bond Avenue, Portland, OR, 97239, USA.
  • Zhao H; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 S. Bond Avenue, Portland, OR, 97239, USA.
  • Wu K; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 S. Bond Avenue, Portland, OR, 97239, USA.
  • Zhang J; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 S. Bond Avenue, Portland, OR, 97239, USA.
  • Hou Z; Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250001, China.
  • So S; Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250001, China.
  • Han J; Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250001, China.
  • Park J; Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250001, China.
  • Kim CJ; Department of Biomedical Science, College of Life Science and CHA Advanced Research Institute, CHA University, Seongnam, Gyeonggi, 13488, Republic of Korea.
  • Zong K; Department of Biomedical Science, College of Life Science and CHA Advanced Research Institute, CHA University, Seongnam, Gyeonggi, 13488, Republic of Korea.
  • Gong J; Stem Cell Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
  • Yuan Y; Stem Cell Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
  • Gu Y; Technology Center of Hefei Customs, Hefei, 230009, Anhui, China.
  • Shen Y; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, 518083, China.
  • Olson SB; China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China.
  • Yang H; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, 518083, China.
  • Battaglia D; China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China.
  • O'Leary T; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, 518083, China.
  • Krieg SA; China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China.
  • Lee DM; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, 518083, China.
  • Wu DH; China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China.
  • Duell PB; Department of Molecular and Medical Genetics and Knight Diagnostic Laboratories, Oregon Health & Science University, Portland, OR, 97239, USA.
  • Kaul S; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Ch
  • Kim JS; Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 S. Bond Avenue, Portland, OR, 97239, USA.
  • Heitner SB; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, 3303 Southwest, Bond Avenue, Portland, OR, 97239, USA.
  • Kang E; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, 3303 Southwest, Bond Avenue, Portland, OR, 97239, USA.
  • Chen ZJ; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, 3303 Southwest, Bond Avenue, Portland, OR, 97239, USA.
  • Amato P; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, 3303 Southwest, Bond Avenue, Portland, OR, 97239, USA.
  • Mitalipov S; Knight Cardiovascular Institute, Oregon Health & Science University, 3181 Southwest, Sam Jackson Park Road, Portland, OR, 97239, USA.
Nat Commun ; 14(1): 1219, 2023 03 07.
Article in En | MEDLINE | ID: mdl-36882397
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blastocyst / Gene Editing Limits: Humans Language: En Journal: Nat Commun Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blastocyst / Gene Editing Limits: Humans Language: En Journal: Nat Commun Year: 2023 Document type: Article