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Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition.
Amin, Mohammed M; Abuo-Rahma, Gamal El-Din A; Shaykoon, Montaser Sh A; Marzouk, Adel A; Abourehab, Mohammed A S; Saraya, Roshdy E; Badr, Mohamed; Sayed, Ahmed M; Beshr, Eman A M.
Affiliation
  • Amin MM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
  • Abuo-Rahma GEA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia 61519, Egypt. Electronic address: gamal.aborahama@mu.edu.eg.
  • Shaykoon MSA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
  • Marzouk AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA.
  • Abourehab MAS; Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
  • Saraya RE; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Port Said University, Port Said 42515, Egypt.
  • Badr M; Department of Biochemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt.
  • Sayed AM; Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, 62513 Beni-Suef, Egypt.
  • Beshr EAM; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Electronic address: eman_beshr@mu.edu.eg.
Bioorg Chem ; 134: 106444, 2023 05.
Article in En | MEDLINE | ID: mdl-36893547
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chalcone / Chalcones / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chalcone / Chalcones / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2023 Document type: Article