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BEX2 is poor prognostic factor and required for cancer stemness in gastric cancer.
Yasumoto, Akihiro; Fujimori, Haruna; Mochizuki, Mai; Shibuya-Takahashi, Rie; Nakamura-Shima, Mao; Shindo, Norihisa; Yamaguchi, Kazunori; Fukushi, Daisuke; Wakui, Yuta; Sugai, Takahiro; Iwai, Wataru; Abue, Makoto; Sato, Ikuro; Satoh, Kennichi; Katayose, Yu; Yasuda, Jun; Shibata, Chikashi; Tamai, Keiichi.
Affiliation
  • Yasumoto A; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan; Division of Gastoroenterologic Surgery, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyaginoku, Sendai, Miyagi, 983-8536, Japan.
  • Fujimori H; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Mochizuki M; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Shibuya-Takahashi R; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Nakamura-Shima M; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Shindo N; Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Yamaguchi K; Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Fukushi D; Division of Gastroenterology, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyaginoku, Sendai, Miyagi, 983-8536, Japan.
  • Wakui Y; Department of Gastroenterology, Miyagi Cancer Center, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Sugai T; Department of Gastroenterology, Miyagi Cancer Center, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Iwai W; Department of Gastroenterology, Miyagi Cancer Center, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Abue M; Department of Gastroenterology, Miyagi Cancer Center, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Sato I; Department of Pathology, Miyagi Cancer Center, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Satoh K; Division of Gastroenterology, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyaginoku, Sendai, Miyagi, 983-8536, Japan.
  • Katayose Y; Division of Hepato-biliary-pancreatic Surgery, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyaginoku, Sendai, Miyagi, 983-8536, Japan.
  • Yasuda J; Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan.
  • Shibata C; Division of Gastoroenterologic Surgery, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyaginoku, Sendai, Miyagi, 983-8536, Japan.
  • Tamai K; Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 47-1, Medeshima-Shiote, Natori, Miyagi, Japan. Electronic address: tamaikeiichi@med.tohoku.ac.jp.
Biochem Biophys Res Commun ; 655: 59-67, 2023 05 07.
Article in En | MEDLINE | ID: mdl-36933308
ABSTRACT
Gastric cancer is the fifth most common malignancy worldwide. However, targeted therapy for advanced gastric cancer is still limited. Here, we report BEX2 (Brain expressed X-linked 2) as a poor prognostic factor in two gastric cancer cohorts. BEX2 expression was increased in spheroid cells, and its knockdown decreased aldefluor activity and cisplatin resistance. BEX2 was found to upregulate CHRNB2 (Cholinergic Receptor Nicotinic Beta 2 Subunit) expression, a cancer stemness-related gene, in a transcriptional manner, and the knockdown of which also decreases aldefluor activity. Collectively, these data are suggestive of the role of BEX2 in the malignant process of gastric cancer, and as a promising therapeutic target.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2023 Document type: Article