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Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease.
Boeynaems, Steven; Ma, X Rosa; Yeong, Vivian; Ginell, Garrett M; Chen, Jian-Hua; Blum, Jacob A; Nakayama, Lisa; Sanyal, Anushka; Briner, Adam; Haver, Delphi Van; Pauwels, Jarne; Ekman, Axel; Schmidt, H Broder; Sundararajan, Kousik; Porta, Lucas; Lasker, Keren; Larabell, Carolyn; Hayashi, Mirian A F; Kundaje, Anshul; Impens, Francis; Obermeyer, Allie; Holehouse, Alex S; Gitler, Aaron D.
Affiliation
  • Boeynaems S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Ma XR; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
  • Yeong V; Therapeutic Innovation Center (THINC), Baylor College of Medicine, Houston, TX 77030, USA.
  • Ginell GM; Center for Alzheimer's and Neurodegenerative Diseases (CAND), Texas Children's Hospital, Houston, TX 77030, USA.
  • Chen JH; Dan L Duncan Comprehensive Cancer Center (DLDCCC), Baylor College of Medicine, Houston, TX 77030, USA.
  • Blum JA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Nakayama L; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Sanyal A; Department of Chemical Engineering, Columbia University, New York, NY, 10027, USA.
  • Briner A; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Haver DV; Center for Biomolecular Condensates, Washington University in St Louis, St. Louis, MO 63130, USA.
  • Pauwels J; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  • Ekman A; Department of Anatomy, University of California, San Francisco, CA 94143, USA.
  • Schmidt HB; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Sundararajan K; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Porta L; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Lasker K; Clem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), The University of Queensland, Brisbane, QLD 4072, Australia.
  • Larabell C; VIB-UGent Center for Medical Biotechnology, 9000 Gent, Belgium.
  • Hayashi MAF; VIB Proteomics Core, 9000 Gent, Belgium.
  • Kundaje A; Department of Biochemistry, Ghent University, 9000 Gent, Belgium.
  • Impens F; VIB-UGent Center for Medical Biotechnology, 9000 Gent, Belgium.
  • Obermeyer A; VIB Proteomics Core, 9000 Gent, Belgium.
  • Holehouse AS; Department of Biochemistry, Ghent University, 9000 Gent, Belgium.
  • Gitler AD; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
bioRxiv ; 2023 Mar 09.
Article in En | MEDLINE | ID: mdl-36945394
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: BioRxiv Year: 2023 Document type: Article