Your browser doesn't support javascript.
loading
Literature review on the use of methoxyflurane in the management of pain in cancer-related procedures.
Finkelstein, Samuel; Oliogu, Etinosa; Yee, Albert; Milton, Lauren; Rivlin, Leon; Henry, Patrick; Behroozian, Tara; Chow, Edward; Finkelstein, Joel.
Affiliation
  • Finkelstein S; Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
  • Oliogu E; Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
  • Yee A; Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
  • Milton L; Division of Orthopaedic Surgery, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
  • Rivlin L; Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
  • Henry P; Humber River Hospital, Toronto, ON, Canada.
  • Behroozian T; Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
  • Chow E; Division of Orthopaedic Surgery, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
  • Finkelstein J; Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Support Care Cancer ; 31(4): 232, 2023 Mar 24.
Article in En | MEDLINE | ID: mdl-36961562
INTRODUCTION: Self-administered methoxyflurane, also known as Penthrox, at a sub-anesthetic dose is a short-term, fast-acting, and safe analgesic that may provide suitable pain relief for cancer patients. This review aims to compile the existing evidence on methoxyflurane and its efficacy in reducing pain during cancer-related procedures. METHODS: A literature search was conducted through OVID Medline and Embase. The search was limited to articles published between 2012 and 2021 and studies were included if they assessed the efficacy of methoxyflurane to reduce pain in cancer-related procedures. All types of cancer were included. RESULTS: The literature search yielded seven studies published between 2012 and 2021. The studies analyzed assessed methoxyflurane use in prostate biopsy, colonoscopy, removal of brachytherapy rods, and bone marrow biopsy. Various research designs were employed, including three randomized controlled trials, two prospective observational studies, one retrospective, and one non-randomized controlled trial. In all, methoxyflurane has a demonstrated ability to reduce pain in these procedures. CONCLUSION: In the limited studies available in evaluating the efficacy of methoxyflurane for reducing procedural pain during cancer-related procedures, all have demonstrated clinical equivalency or superiority. Pain relief appears to be equivalent however methoxyflurane overcomes the standard limitations of respiratory sedation and has demonstrated quicker procedural recovery times than traditional sedation methods. The accumulated data to date supports the use of methoxyflurane which can supplement or supplant current methods of analgesia in cancer-related procedures.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anesthetics, Inhalation / Cancer Pain / Neoplasms Type of study: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Limits: Humans / Male Language: En Journal: Support Care Cancer Year: 2023 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anesthetics, Inhalation / Cancer Pain / Neoplasms Type of study: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Limits: Humans / Male Language: En Journal: Support Care Cancer Year: 2023 Document type: Article