[The early use of glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes and high cardiovascular risk]. / L'impiego degli agonisti recettoriali del glucagon-like peptide 1 nel trattamento precoce e nel continuum cardiovascolare dei pazienti con diabete di tipo 2 ad alto rischio cardiovascolare.
G Ital Cardiol (Rome)
; 24(4): 285-292, 2023 Apr.
Article
in It
| MEDLINE
| ID: mdl-36971172
ABSTRACT
Patients with type 2 diabetes mellitus are at an increased risk of cardiovascular disease and microvascular and macrovascular complications. Although multiple classes of antidiabetic drugs are currently available, cardiovascular complications of diabetes still cause considerable morbidity and premature cardiovascular mortality in diabetic patients. The development of new drugs represented a conceptual breakthrough in the treatment of patients with type 2 diabetes mellitus. In addition to improving glycemic homeostasis, these new treatments have consistently demonstrated relevant cardiovascular and renal benefits due to their multiple pleiotropic effects. The aim of this review is to analyze the direct and indirect mechanisms by which glucagon-like peptide 1 receptor agonists favorably impact cardiovascular outcome and report current indications for their implementation in clinical practice based on national and international guidelines.
Full text:
1
Collection:
01-internacional
Health context:
1_ASSA2030
/
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
/
Diabetes Mellitus, Type 2
/
Hypoglycemic Agents
Type of study:
Etiology_studies
/
Guideline
/
Risk_factors_studies
Limits:
Humans
Language:
It
Journal:
G Ital Cardiol (Rome)
Year:
2023
Document type:
Article