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Personalised virtual brain models in epilepsy.
Jirsa, Viktor; Wang, Huifang; Triebkorn, Paul; Hashemi, Meysam; Jha, Jayant; Gonzalez-Martinez, Jorge; Guye, Maxime; Makhalova, Julia; Bartolomei, Fabrice.
Affiliation
  • Jirsa V; Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Aix Marseille Université, Marseille, France. Electronic address: viktor.jirsa@univ-amu.fr.
  • Wang H; Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Aix Marseille Université, Marseille, France.
  • Triebkorn P; Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Aix Marseille Université, Marseille, France.
  • Hashemi M; Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Aix Marseille Université, Marseille, France.
  • Jha J; Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Aix Marseille Université, Marseille, France.
  • Gonzalez-Martinez J; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Guye M; Centre National de la Recherche Scientifique, Center for Magnetic Resonance in Biology and Medicine, Aix Marseille Université, Marseille, France; Centre d'Exploration Métabolique par Résonance Magnétique, Assistance Publique - Hôpitaux de Marseille, La Timone University Hospital, Marseille, France.
  • Makhalova J; Centre National de la Recherche Scientifique, Center for Magnetic Resonance in Biology and Medicine, Aix Marseille Université, Marseille, France; Centre d'Exploration Métabolique par Résonance Magnétique, Assistance Publique - Hôpitaux de Marseille, La Timone University Hospital, Marseille, France;
  • Bartolomei F; Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Aix Marseille Université, Marseille, France; Epileptology and Clinical Neurophysiology Department, Assistance Publique - Hôpitaux de Marseille, La Timone University Hospital, Marseille, F
Lancet Neurol ; 22(5): 443-454, 2023 05.
Article in En | MEDLINE | ID: mdl-36972720
Individuals with drug-resistant focal epilepsy are candidates for surgical treatment as a curative option. Before surgery can take place, the patient must have a presurgical evaluation to establish whether and how surgical treatment might stop their seizures without causing neurological deficits. Virtual brains are a new digital modelling technology that map the brain network of a person with epilepsy, using data derived from MRI. This technique produces a computer simulation of seizures and brain imaging signals, such as those that would be recorded with intracranial EEG. When combined with machine learning, virtual brains can be used to estimate the extent and organisation of the epileptogenic zone (ie, the brain regions related to seizure generation and the spatiotemporal dynamics during seizure onset). Virtual brains could, in the future, be used for clinical decision making, to improve precision in localisation of seizure activity, and for surgical planning, but at the moment these models have some limitations, such as low spatial resolution. As evidence accumulates in support of the predictive power of personalised virtual brain models, and as methods are tested in clinical trials, virtual brains might inform clinical practice in the near future.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epilepsy / Drug Resistant Epilepsy Type of study: Prognostic_studies Limits: Humans Language: En Journal: Lancet Neurol Year: 2023 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epilepsy / Drug Resistant Epilepsy Type of study: Prognostic_studies Limits: Humans Language: En Journal: Lancet Neurol Year: 2023 Document type: Article