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Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Green, Alanna C; Marttila, Petra; Kiweler, Nicole; Chalkiadaki, Christina; Wiita, Elisée; Cookson, Victoria; Lesur, Antoine; Eiden, Kim; Bernardin, François; Vallin, Karl S A; Borhade, Sanjay; Long, Maeve; Ghahe, Elahe Kamali; Jiménez-Alonso, Julio J; Jemth, Ann-Sofie; Loseva, Olga; Mortusewicz, Oliver; Meyers, Marianne; Viry, Elodie; Johansson, Annika I; Hodek, Ondrej; Homan, Evert; Bonagas, Nadilly; Ramos, Louise; Sandberg, Lars; Frödin, Morten; Moussay, Etienne; Slipicevic, Ana; Letellier, Elisabeth; Paggetti, Jérôme; Sørensen, Claus Storgaard; Helleday, Thomas; Henriksson, Martin; Meiser, Johannes.
Affiliation
  • Green AC; Weston Park Cancer Centre and Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK.
  • Marttila P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Kiweler N; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
  • Chalkiadaki C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Wiita E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Cookson V; Weston Park Cancer Centre and Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK.
  • Lesur A; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
  • Eiden K; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
  • Bernardin F; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
  • Vallin KSA; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Borhade S; RISE Research Institutes of Sweden, Södertälje, Sweden.
  • Long M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Ghahe EK; RedGlead Discover, Lund, Sweden.
  • Jiménez-Alonso JJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Jemth AS; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
  • Loseva O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Mortusewicz O; Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain.
  • Meyers M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Viry E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Johansson AI; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Hodek O; Faculty of Science, Technology and Medicine, Department of Life Sciences and Medicine, Molecular Disease Mechanisms Group, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
  • Homan E; Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
  • Bonagas N; Swedish Metabolomics Centre, Department of Plant Physiology, Umeå University, Umeå, Sweden.
  • Ramos L; Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå, Sweden.
  • Sandberg L; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Frödin M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Moussay E; Weston Park Cancer Centre and Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK.
  • Slipicevic A; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden.
  • Letellier E; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
  • Paggetti J; Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
  • Sørensen CS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Helleday T; One-carbon Therapeutics AB, Stockholm, Sweden.
  • Henriksson M; Faculty of Science, Technology and Medicine, Department of Life Sciences and Medicine, Molecular Disease Mechanisms Group, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
  • Meiser J; Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
Nat Metab ; 5(4): 642-659, 2023 04.
Article in En | MEDLINE | ID: mdl-37012496
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Methylenetetrahydrofolate Dehydrogenase (NADP) / Neoplasms Language: En Journal: Nat Metab Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Methylenetetrahydrofolate Dehydrogenase (NADP) / Neoplasms Language: En Journal: Nat Metab Year: 2023 Document type: Article