Transient Receptor Potential Canonical 5 (TRPC5) Channels Activator, BTD [N-{3-(adamantan-2-yloxy)-propyl}-3-(6-methyl-1,1-dioxo-2H-1&#955;<sup>6</sup>,2,4- benzothiadiazin-3-yl)-propanamide)] Ameliorates Diabetic Cardiac Autonomic Neuropathy in Rats.

Adhya, Pratik; Sharma, Shyam Sunder

Transient Receptor Potential Canonical 5 (TRPC5) Channels Activator, BTD [N-{3-(adamantan-2-yloxy)-propyl}-3-(6-methyl-1,1-dioxo-2H-1λ⁶,2,4- benzothiadiazin-3-yl)-propanamide)] Ameliorates Diabetic Cardiac Autonomic Neuropathy in Rats.

Adhya, Pratik; Sharma, Shyam Sunder.

Affiliation

Adhya P; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Nagar (Mohali), 160 062, Punjab, India.
Sharma SS; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Nagar (Mohali), 160 062, Punjab, India.

Curr Neurovasc Res ; 20(1): 112-123, 2023.

Article in En | MEDLINE | ID: mdl-37013433

Subject(s)

Diabetes Mellitus, Experimental; Diabetic Neuropathies; TRPC Cation Channels; Animals; Male; Rats; Diabetes Mellitus, Experimental/complications; Diabetic Neuropathies/drug therapy; Heart/innervation; Heart Rate; Rats, Sprague-Dawley; TRPC Cation Channels/agonists

Key words

BTD; Diabetic cardiac autonomic neuropathy; TRPC5; TRPC5 activator; diabetic complications; parasympathetic system; vagus nerve

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Experimental / Diabetic Neuropathies / TRPC Cation Channels Limits: Animals Language: En Journal: Curr Neurovasc Res Year: 2023 Document type: Article

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