Examining dietary acid load in individuals with type 2 diabetes: a case-control study.

ABSTRACT

OBJECTIVE: Diabetes is a chronic disease that can cause various complications and has a high prevalence. Evidence increasingly shows that acid-base homeostasis is critical to maintaining normal metabolic function. This case-control study aims to evaluate the relationship between dietary acid load and the risk of type 2 diabetes. PATIENTS AND METHODS: This study recruited 204 participants, 92 of whom had just been diagnosed with type 2 diabetes, and 102 healthy controls who were matched in age and gender as controls. Twenty-four dietary recall was used for dietary intake assessments. Dietary acid load was approximated using two different methods: potential renal acid load (PRAL) and net endogenous acid production (NEAP), both calculated from dietary recalls. RESULTS: In the case and control groups, the dietary acid load mean scores were 4.18±26.8, 20.84±29.54 mEq/day for PRAL, and 55.11±29.23, 68.43±32.23 mEq/day for NEAP, respectively. When it came to the multiple possible confounders, the participants in the highest tertile of PRAL (OR 4.43, 95% CI 1.38-23.81, ptrend<0.001) and NEAP (OR 3.15, 95% CI 1.53-9.59, ptrend<0.001) had a significantly higher risk of developing type 2 diabetes compared to those in the lowest tertile. CONCLUSIONS: The findings of the present study suggest that a high acid load in the diet may increase the risk of type 2 diabetes. Therefore, it is possible that limiting dietary acid load could lower type 2 diabetes risk in vulnerable individuals.