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Cross-sectional versus longitudinal cognitive assessments for the diagnosis of symptomatic Alzheimer's disease in adults with Down syndrome.
Videla, Laura; Benejam, Bessy; Carmona-Iragui, María; Barroeta, Isabel; Fernández, Susana; Arranz, Javier; Azzahchi, Sumia Elbachiri; Altuna, Miren; Padilla, Concepción; Valldeneu, Silvia; Pegueroles, Jordi; Montal, Víctor; Aranha, Mateus Rozalem; Vaqué-Alcázar, Lídia; Iulita, Maria Florencia; Alcolea, Daniel; Bejanin, Alexandre; Videla, Sebastià; Blesa, Rafael; Lleó, Alberto; Fortea, Juan.
Affiliation
  • Videla L; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Benejam B; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain.
  • Carmona-Iragui M; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
  • Barroeta I; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain.
  • Fernández S; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Arranz J; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain.
  • Azzahchi SE; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
  • Altuna M; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Padilla C; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
  • Valldeneu S; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain.
  • Pegueroles J; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Montal V; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Aranha MR; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Vaqué-Alcázar L; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
  • Iulita MF; CITA-alzheimer foundation, Donostia-San Sebsatián, Spain.
  • Alcolea D; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Bejanin A; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Videla S; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
  • Blesa R; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Lleó A; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
  • Fortea J; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Alzheimers Dement ; 19(9): 3916-3925, 2023 09.
Article in En | MEDLINE | ID: mdl-37038748
BACKGROUND: Down syndrome (DS) is a genetic form of Alzheimer's disease (AD). However, clinical diagnosis is difficult, and experts emphasize the need for detecting intra-individual cognitive decline. OBJECTIVE: To compare the performance of baseline and longitudinal neuropsychological assessments for the diagnosis of symptomatic AD in DS. METHODS: Longitudinal cohort study of adults with DS. Individuals were classified as asymptomatic, prodromal AD, or AD dementia. We performed receiver operating characteristic curve analyses to compare baseline and longitudinal changes of CAMCOG-DS and mCRT. RESULTS: We included 562 adults with DS. Baseline assessments showed good to excellent diagnostic performance for AD dementia (AUCs between 0.82 and 0.99) and prodromal AD, higher than the 1-year intra-individual cognitive decline (area under the ROC curve between 0.59 and 0.79 for AD dementia, lower for prodromal AD). Longer follow-ups increased the diagnostic performance of the intra-individual cognitive decline. DISCUSSION: Baseline cognitive assessment outperforms the 1-year intra-individual cognitive decline in adults with DS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Down Syndrome / Alzheimer Disease / Cognitive Dysfunction Type of study: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Humans Language: En Journal: Alzheimers Dement Year: 2023 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Down Syndrome / Alzheimer Disease / Cognitive Dysfunction Type of study: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Humans Language: En Journal: Alzheimers Dement Year: 2023 Document type: Article