Disrupted resting-sate brain network dynamics in children born extremely preterm.
Cereb Cortex
; 33(13): 8101-8109, 2023 06 20.
Article
in En
| MEDLINE
| ID: mdl-37083266
ABSTRACT
The developing brain has to adapt to environmental and intrinsic insults after extremely preterm (EPT) birth. Ongoing maturational processes maximize their fit to the environment and this can provide a substrate for neurodevelopmental failures. Resting-state functional magnetic resonance imaging was used to scan 33 children born EPT, at < 27 weeks of gestational age, and 26 full-term controls at 10 years of age. We studied the capability of a brain area to propagate neural information (intrinsic ignition) and its variability across time (node-metastability). This framework was computed for the dorsal attention network (DAN), frontoparietal, default-mode network (DMN), and the salience, limbic, visual, and somatosensory networks. The EPT group showed reduced intrinsic ignition in the DMN and DAN, compared with the controls, and reduced node-metastability in the DMN, DAN, and salience networks. Intrinsic ignition and node-metastability values correlated with cognitive performance at 12 years of age in both groups, but only survived in the term group after adjustment. Preterm birth disturbed the signatures of functional brain organization at rest in 3 core high-order networks DMN, salience, and DAN. Identifying vulnerable resting-state networks after EPT birth may lead to interventions that aim to rebalance brain function.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rest
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Brain
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Infant, Extremely Premature
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Nerve Net
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Neural Pathways
Limits:
Child
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Female
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Humans
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Male
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Newborn
Language:
En
Journal:
Cereb Cortex
Year:
2023
Document type:
Article