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Characterization of a Novel African Swine Fever Virus p72 Genotype II from Nigeria.
Ambagala, Aruna; Goonewardene, Kalhari; Lamboo, Lindsey; Goolia, Melissa; Erdelyan, Cassidy; Fisher, Mathew; Handel, Katherine; Lung, Oliver; Blome, Sandra; King, Jacqueline; Forth, Jan Hendrik; Calvelage, Sten; Spinard, Edward; Gladue, Douglas P; Masembe, Charles; Adedeji, Adeyinka J; Olubade, Toyin; Maurice, Nanven A; Ularamu, Hussaini G; Luka, Pam D.
Affiliation
  • Ambagala A; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.
  • Goonewardene K; Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
  • Lamboo L; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.
  • Goolia M; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.
  • Erdelyan C; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.
  • Fisher M; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.
  • Handel K; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.
  • Lung O; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.
  • Blome S; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.
  • King J; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald, Germany.
  • Forth JH; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald, Germany.
  • Calvelage S; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald, Germany.
  • Spinard E; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald, Germany.
  • Gladue DP; Plum Island Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Greenport, NY 11944, USA.
  • Masembe C; Plum Island Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Greenport, NY 11944, USA.
  • Adedeji AJ; College of Natural Resources (CoNAS), Makerere University, Kampala P.O Box 7062, Uganda.
  • Olubade T; National Veterinary Research Institute, Vom 930103, Nigeria.
  • Maurice NA; National Veterinary Research Institute, Vom 930103, Nigeria.
  • Ularamu HG; National Veterinary Research Institute, Vom 930103, Nigeria.
  • Luka PD; National Veterinary Research Institute, Vom 930103, Nigeria.
Viruses ; 15(4)2023 04 02.
Article in En | MEDLINE | ID: mdl-37112895
ABSTRACT
African swine fever (ASF) is a high-consequence transboundary hemorrhagic fever of swine. It continues to spread across the globe causing socio-economic issues and threatening food security and biodiversity. In 2020, Nigeria reported a major ASF outbreak, killing close to half a million pigs. Based on the partial sequences of the genes B646L (p72) and E183L (p54), the virus responsible for the outbreak was identified as an African swine fever virus (ASFV) p72 genotype II. Here, we report further characterization of ASFV RV502, one of the isolates obtained during the outbreak. The whole genome sequence of this virus revealed a deletion of 6535 bp between the nucleotide positions 11,760-18,295 of the genome, and an apparent reverse complement duplication of the 5' end of the genome at the 3' end. Phylogenetically, ASFV RV502 clustered together with ASFV MAL/19/Karonga and ASFV Tanzania/Rukwa/2017/1 suggesting that the virus responsible for the 2020 outbreak in Nigeria has a South-eastern African origin.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: African Swine Fever / African Swine Fever Virus Limits: Animals Country/Region as subject: Africa Language: En Journal: Viruses Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: African Swine Fever / African Swine Fever Virus Limits: Animals Country/Region as subject: Africa Language: En Journal: Viruses Year: 2023 Document type: Article