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Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy.
Chen, Yu-Jia; Li, Guan-Nan; Li, Xian-Jing; Wei, Lin-Xing; Fu, Min-Jie; Cheng, Zhou-Li; Yang, Zhen; Zhu, Gui-Qi; Wang, Xu-Dong; Zhang, Cheng; Zhang, Jin-Ye; Sun, Yi-Ping; Saiyin, Hexige; Zhang, Jin; Liu, Wei-Ren; Zhu, Wen-Wei; Guan, Kun-Liang; Xiong, Yue; Yang, Yong; Ye, Dan; Chen, Lei-Lei.
Affiliation
  • Chen YJ; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology); Key Laboratory of Metabolism and Molecular Medicine (Min
  • Li GN; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology); Key Laboratory of Metabolism and Molecular Medicine (Min
  • Li XJ; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China.
  • Wei LX; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology); Key Laboratory of Metabolism and Molecular Medicine (Min
  • Fu MJ; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
  • Cheng ZL; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology); Key Laboratory of Metabolism and Molecular Medicine (Min
  • Yang Z; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology); Key Laboratory of Metabolism and Molecular Medicine (Min
  • Zhu GQ; Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of the Ministry of Education, Shanghai, China.
  • Wang XD; Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, and Bone Marrow for Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
  • Zhang C; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology); Key Laboratory of Metabolism and Molecular Medicine (Min
  • Zhang JY; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology); Key Laboratory of Metabolism and Molecular Medicine (Min
  • Sun YP; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology); Key Laboratory of Metabolism and Molecular Medicine (Min
  • Saiyin H; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China.
  • Zhang J; Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, and Bone Marrow for Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
  • Liu WR; Zhejiang Laboratory for Systems and Precision Medicine, Zhejiang University Medical Center, Hangzhou 311121, Zhejiang Province, China.
  • Zhu WW; Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of the Ministry of Education, Shanghai, China.
  • Guan KL; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
  • Xiong Y; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92037, USA.
  • Yang Y; Cullgen Inc., 12671 High Bluff Drive, San Diego, CA 92130, USA.
  • Ye D; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China.
  • Chen LL; Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology); Key Laboratory of Metabolism and Molecular Medicine (Min
Sci Adv ; 9(17): eadg0654, 2023 04 28.
Article in En | MEDLINE | ID: mdl-37115931
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor-Associated Macrophages / Neoplasms Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Sci Adv Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor-Associated Macrophages / Neoplasms Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Sci Adv Year: 2023 Document type: Article