Folic acid and chromosome breakage. IV. Variance estimates from longitudinal studies of normal individuals and their implications for sample size and power to detect differences between populations.
Mutat Res
; 174(2): 115-9, 1986 Jun.
Article
in En
| MEDLINE
| ID: mdl-3713728
ABSTRACT
The frequency of chromosome aberrations was studied in minimal essential medium (MEM) with and without folic acid (FA) in lymphocytes of 4 normal individuals, each sampled 12 times over a 1-year period. The cells cultured without FA had significantly more breaks and gaps. In both media about 75% of aberrations were classified as gaps. Calculations based on variance estimates suggest that the use of medium without FA could enhance the statistical power to distinguish differences in proportions of chromosome breakage between groups in the same study.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphocytes
/
Chromosome Aberrations
/
Folic Acid
Type of study:
Observational_studies
Limits:
Humans
Language:
En
Journal:
Mutat Res
Year:
1986
Document type:
Article