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AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins.
Shi, Gongyu; Scott, Helen; Azhar, Nur Izzah Farhana Mohamad; Gialeli, Andriana; Clennell, Benjamin; Lee, Keng Siang; Hurcombe, Jenny; Whitcomb, Daniel; Coward, Richard; Wong, Liang-Fong; Cordero-Llana, Oscar; Uney, James B.
Affiliation
  • Shi G; Bristol Medical School, Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.
  • Scott H; Bristol Medical School, Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.
  • Azhar NIFM; Bristol Medical School, Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.
  • Gialeli A; Bristol Medical School, Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.
  • Clennell B; Bristol Medical School, Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.
  • Lee KS; Bristol Medical School, Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.
  • Hurcombe J; Bristol Medical School, Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.
  • Whitcomb D; Bristol Renal, Dorothy Hodgkin Building, University of Bristol, Bristol, BS1 3NY, UK.
  • Coward R; Bristol Medical School, Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.
  • Wong LF; Bristol Medical School, Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.
  • Cordero-Llana O; Bristol Renal, Dorothy Hodgkin Building, University of Bristol, Bristol, BS1 3NY, UK.
  • Uney JB; Bristol Medical School, Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK.
Sci Rep ; 13(1): 8334, 2023 05 23.
Article in En | MEDLINE | ID: mdl-37221196
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rotenone / Neurons Limits: Humans Language: En Journal: Sci Rep Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rotenone / Neurons Limits: Humans Language: En Journal: Sci Rep Year: 2023 Document type: Article