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Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis.
O'Sullivan, Eoin D; Mylonas, Katie J; Xin, Cuiyan; Baird, David P; Carvalho, Cyril; Docherty, Marie-Helena; Campbell, Ross; Matchett, Kylie P; Waddell, Scott H; Walker, Alexander D; Gallagher, Kevin M; Jia, Siyang; Leung, Steve; Laird, Alexander; Wilflingseder, Julia; Willi, Michaela; Reck, Maximilian; Finnie, Sarah; Pisco, Angela; Gordon-Keylock, Sabrina; Medvinsky, Alexander; Boulter, Luke; Henderson, Neil C; Kirschner, Kristina; Chandra, Tamir; Conway, Bryan R; Hughes, Jeremy; Denby, Laura; Bonventre, Joseph V; Ferenbach, David A.
Affiliation
  • O'Sullivan ED; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Mylonas KJ; Kidney Health Service, Royal Brisbane and Women's Hospital, Brisbane, Queensland 4029, Australia.
  • Xin C; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Baird DP; Renal Division and Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Carvalho C; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Docherty MH; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Campbell R; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Matchett KP; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Waddell SH; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Walker AD; Cancer Research UK Scotland Centre and MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.
  • Gallagher KM; Cancer Research UK Scotland Centre and MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.
  • Jia S; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Leung S; Department of Urology, Western General Hospital, Edinburgh EH4 2XU, UK.
  • Laird A; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Wilflingseder J; Department of Urology, Western General Hospital, Edinburgh EH4 2XU, UK.
  • Willi M; Department of Urology, Western General Hospital, Edinburgh EH4 2XU, UK.
  • Reck M; Renal Division and Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Finnie S; Department of Physiology and Pathophysiology, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria.
  • Pisco A; Laboratory of Genetics and Physiology, NIDDK, NIH, Bethesda, MD 20892, USA.
  • Gordon-Keylock S; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Medvinsky A; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Boulter L; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
  • Henderson NC; Centre for Regenerative Medicine. University of Edinburgh, Edinburgh EH16 4UU, UK.
  • Kirschner K; Centre for Regenerative Medicine. University of Edinburgh, Edinburgh EH16 4UU, UK.
  • Chandra T; Cancer Research UK Scotland Centre and MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.
  • Conway BR; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Hughes J; Cancer Research UK Scotland Centre and MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.
  • Denby L; School of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Bonventre JV; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
  • Ferenbach DA; Cancer Research UK Scotland Centre and MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.
Sci Transl Med ; 15(698): eabn0736, 2023 05 31.
Article in En | MEDLINE | ID: mdl-37256934
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renal Insufficiency, Chronic / Hedgehog Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Transl Med Year: 2023 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renal Insufficiency, Chronic / Hedgehog Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Transl Med Year: 2023 Document type: Article