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A novel dual-plasmid platform provides scalable transfection yielding improved productivity and packaging across multiple AAV serotypes and genomes.
van Lieshout, Laura P; Rubin, Miranda; Costa-Grant, Katrina; Ota, Stacy; Golebiowski, Diane; Panico, Troy; Wiberg, Eli; Szymczak, Klaudia; Gilmore, Richard; Stanvick, Marissa; Burnham, Brenda; Gagnon, Jeff; Iwuchukwu, Ifeyinwa; Yang, Guang; Ghazi, Iraj; Meola, Alex; Dickerson, Ryan; Thiers, Thomas; Mustich, Luke; Hayes, April; Rivas, Israel; Lotterhand, Jason; Avila, Nancy; McGivney, James; Yin, Jin; Kelly, Tim.
Affiliation
  • van Lieshout LP; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Rubin M; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA.
  • Costa-Grant K; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Ota S; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Golebiowski D; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Panico T; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Wiberg E; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Szymczak K; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Gilmore R; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Stanvick M; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Burnham B; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Gagnon J; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Iwuchukwu I; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Yang G; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Ghazi I; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Meola A; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Dickerson R; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Thiers T; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Mustich L; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Hayes A; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA.
  • Rivas I; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA.
  • Lotterhand J; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA.
  • Avila N; Homology Medicines, Inc., 1 Patriots Park, Bedford, MA 01730, USA.
  • McGivney J; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Yin J; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
  • Kelly T; Oxford Biomedica Solutions LLC, 1 Patriots Park, Bedford, MA 01730, USA.
Mol Ther Methods Clin Dev ; 29: 426-436, 2023 Jun 08.
Article in En | MEDLINE | ID: mdl-37273900
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mol Ther Methods Clin Dev Year: 2023 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mol Ther Methods Clin Dev Year: 2023 Document type: Article