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Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Ryan, Tristram A J; Hooftman, Alexander; Rehill, Aisling M; Johansen, Matt D; Brien, Eóin C O'; Toller-Kawahisa, Juliana E; Wilk, Mieszko M; Day, Emily A; Weiss, Hauke J; Sarvari, Pourya; Vozza, Emilio G; Schramm, Fabian; Peace, Christian G; Zotta, Alessia; Miemczyk, Stefan; Nalkurthi, Christina; Hansbro, Nicole G; McManus, Gavin; O'Doherty, Laura; Gargan, Siobhan; Long, Aideen; Dunne, Jean; Cheallaigh, Clíona Ní; Conlon, Niall; Carty, Michael; Fallon, Padraic G; Mills, Kingston H G; Creagh, Emma M; Donnell, James S O'; Hertzog, Paul J; Hansbro, Philip M; McLoughlin, Rachel M; Wygrecka, Malgorzata; Preston, Roger J S; Zaslona, Zbigniew; O'Neill, Luke A J.
Affiliation
  • Ryan TAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Hooftman A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Rehill AM; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland.
  • Johansen MD; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia.
  • Brien ECO; Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Toller-Kawahisa JE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Wilk MM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Day EA; Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
  • Weiss HJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Sarvari P; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Vozza EG; Center for Infection and Genomics of the Lung, German Center for Lung Research (DZL), Faculty of Medicine, Justus Liebig University, Giessen, Germany.
  • Schramm F; Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Peace CG; Center for Infection and Genomics of the Lung, German Center for Lung Research (DZL), Faculty of Medicine, Justus Liebig University, Giessen, Germany.
  • Zotta A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Miemczyk S; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Nalkurthi C; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia.
  • Hansbro NG; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia.
  • McManus G; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia.
  • O'Doherty L; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Gargan S; Department of Infectious Diseases, St. James's Hospital, Dublin, Ireland.
  • Long A; Clinical Research Facility, St. James's Hospital, Dublin, Ireland.
  • Dunne J; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Cheallaigh CN; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Conlon N; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Carty M; Department of Immunology, St James's Hospital, Dublin, Ireland.
  • Fallon PG; Department of Infectious Diseases, St. James's Hospital, Dublin, Ireland.
  • Mills KHG; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Creagh EM; Clinical Research Facility, St. James's Hospital, Dublin, Ireland.
  • Donnell JSO; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Hertzog PJ; Department of Immunology, St James's Hospital, Dublin, Ireland.
  • Hansbro PM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • McLoughlin RM; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Wygrecka M; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.
  • Preston RJS; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Zaslona Z; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • O'Neill LAJ; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland.
Nat Commun ; 14(1): 3513, 2023 06 14.
Article in En | MEDLINE | ID: mdl-37316487
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Thrombosis / Interferon Type I / COVID-19 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Commun Year: 2023 Document type: Article
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Thrombosis / Interferon Type I / COVID-19 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Commun Year: 2023 Document type: Article