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Enabling a universal lateral flow readout for DNA strand displacement via disassembling chemical labels.
Peng, Wanting; Tan, Yun; Shen, Chenlan; Tang, Yanan; Li, Feng.
Affiliation
  • Peng W; Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Analytical & Testing Center, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, P. R. China. windtalker_1205@scu.edu.cn.
  • Tan Y; Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Analytical & Testing Center, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, P. R. China. windtalker_1205@scu.edu.cn.
  • Shen C; Department of Laboratory Medicine, Med + X Center for Manufacturing, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China.
  • Tang Y; Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Analytical & Testing Center, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, P. R. China. windtalker_1205@scu.edu.cn.
  • Li F; Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Analytical & Testing Center, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, P. R. China. windtalker_1205@scu.edu.cn.
Chem Commun (Camb) ; 59(57): 8803-8805, 2023 Jul 13.
Article in En | MEDLINE | ID: mdl-37366312
ABSTRACT
Herein, we describe a novel strategy that enables lateral flow readout for DNA strand displacement via disassembling chemical labels (DCL). Comparing it to a classic fluorogenic assay, we demonstrate that our DCL-based lateral flow assay is highly sensitive and specific, capable of discriminating single nucleotide variants in buccal swab samples.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biosensing Techniques Language: En Journal: Chem Commun (Camb) Year: 2023 Document type: Article
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biosensing Techniques Language: En Journal: Chem Commun (Camb) Year: 2023 Document type: Article