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Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans.
Lutz, Joshua A; Sulima, Agnieszka; Gutman, Eugene S; Bow, Eric W; Luo, Dan; Kaska, Sophia; Prisinzano, Thomas E; Paronis, Carol A; Bergman, Jack; Imler, Gregory H; Kerr, Andrew T; Jacobson, Arthur E; Rice, Kenner C.
Affiliation
  • Lutz JA; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center
  • Sulima A; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center
  • Gutman ES; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center
  • Bow EW; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center
  • Luo D; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone Street, Lexington, KY 40536, USA.
  • Kaska S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone Street, Lexington, KY 40536, USA.
  • Prisinzano TE; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone Street, Lexington, KY 40536, USA.
  • Paronis CA; McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
  • Bergman J; McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
  • Imler GH; Center for Biomolecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375-0001, USA.
  • Kerr AT; Center for Biomolecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375-0001, USA.
  • Jacobson AE; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center
  • Rice KC; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center
Molecules ; 28(12)2023 Jun 15.
Article in En | MEDLINE | ID: mdl-37375350
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Opioid, mu / Morphinans Language: En Journal: Molecules Year: 2023 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Opioid, mu / Morphinans Language: En Journal: Molecules Year: 2023 Document type: Article