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Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Rao, Srinivasa P S; Gould, Matthew K; Noeske, Jonas; Saldivia, Manuel; Jumani, Rajiv S; Ng, Pearly S; René, Olivier; Chen, Yen-Liang; Kaiser, Marcel; Ritchie, Ryan; Francisco, Amanda Fortes; Johnson, Nila; Patra, Debjani; Cheung, Harry; Deniston, Colin; Schenk, Andreas D; Cortopassi, Wilian A; Schmidt, Remo S; Wiedemar, Natalie; Thomas, Bryanna; Palkar, Rima; Ghafar, Nahdiyah A; Manoharan, Vanessa; Luu, Catherine; Gable, Jonathan E; Wan, Kah Fei; Myburgh, Elmarie; Mottram, Jeremy C; Barnes, Whitney; Walker, John; Wartchow, Charles; Aziz, Natasha; Osborne, Colin; Wagner, Juergen; Sarko, Christopher; Kelly, John M; Manjunatha, Ujjini H; Mäser, Pascal; Jiricek, Jan; Lakshminarayana, Suresh B; Barrett, Michael P; Diagana, Thierry T.
Affiliation
  • Rao SPS; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.
  • Gould MK; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Noeske J; Novartis Institute for Tropical Diseases, Singapore.
  • Saldivia M; College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Jumani RS; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Ng PS; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.
  • René O; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Chen YL; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.
  • Kaiser M; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Ritchie R; Novartis Institute for Tropical Diseases, Singapore.
  • Francisco AF; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.
  • Johnson N; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Patra D; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.
  • Cheung H; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Deniston C; Novartis Institute for Tropical Diseases, Singapore.
  • Schenk AD; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.
  • Cortopassi WA; Faculty of Science, University of Basel, Basel, Switzerland.
  • Schmidt RS; College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Wiedemar N; London School of Hygiene and Tropical Medicine, London, UK.
  • Thomas B; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.
  • Palkar R; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.
  • Ghafar NA; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Manoharan V; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.
  • Luu C; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Gable JE; Novartis Institutes for BioMedical Research, San Diego, CA, USA.
  • Wan KF; Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Myburgh E; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Mottram JC; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.
  • Barnes W; Faculty of Science, University of Basel, Basel, Switzerland.
  • Walker J; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.
  • Wartchow C; Faculty of Science, University of Basel, Basel, Switzerland.
  • Aziz N; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.
  • Osborne C; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Wagner J; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.
  • Sarko C; Novartis Institute for Tropical Diseases, Singapore.
  • Kelly JM; Novartis Institute for Tropical Diseases, Singapore.
  • Manjunatha UH; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Mäser P; Novartis Institute for Tropical Diseases, Emeryville, CA, USA.
  • Jiricek J; Novartis Institutes for BioMedical Research, Emeryville, CA, USA.
  • Lakshminarayana SB; Novartis Institute for Tropical Diseases, Singapore.
  • Barrett MP; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK.
  • Diagana TT; York Biomedical Research Institute, Department of Biology, University of York, York, UK.
Science ; 380(6652): 1349-1356, 2023 06 30.
Article in En | MEDLINE | ID: mdl-37384702
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Triazoles / Trypanosoma / Trypanosomiasis, African / Chagas Disease / Topoisomerase II Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Science Year: 2023 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Triazoles / Trypanosoma / Trypanosomiasis, African / Chagas Disease / Topoisomerase II Inhibitors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Science Year: 2023 Document type: Article