The burden of disease for children born alive with Turner syndrome-A European cohort study.
Birth Defects Res
; 115(16): 1459-1468, 2023 10 01.
Article
in En
| MEDLINE
| ID: mdl-37493268
ABSTRACT
BACKGROUND:
Turner syndrome is a rare congenital anomaly caused by complete or partial X chromosome monosomy that may affect mortality and morbidity in childhood.METHODS:
This population-based data-linkage cohort study, as part of the EUROlinkCAT project, investigated mortality and morbidity for the first 5 years of life for liveborn European children diagnosed with Turner syndrome. Thirteen population-based registries in 10 countries from the European surveillance of congenital anomalies (EUROCAT) network participated. Data on children born 1995-2014 and diagnosed with Turner syndrome were linked to mortality, hospital and prescription records. Children with any congenital anomaly and children without a congenital anomaly were included for comparison on morbidity.RESULTS:
Out of a population of 5.8 million livebirths 404 were diagnosed with Turner syndrome prenatally or in infancy and 95.5% survived to their fifth birthday. During the first year of life 72.3% (95% CI 59.5;81.6) of children with Turner syndrome were hospitalized, the median length of stay was 5.6 days (95% CI 3.5;7.7) and 18.7% (95% CI 13.9;23.9) underwent surgery. After the first year of life hospitalizations and length of stay decreased but more children underwent surgery (30.8% [95% CI 17.6;44.7]). In the first 5 years the percentage of children with Turner syndrome having a prescription for antibiotics was 12%-20% per year and increased with the age of child.CONCLUSIONS:
In the first year of life, the burden of disease was relatively high for children with Turner syndrome. The outlook is more positive beyond the first year, though overall morbidity still exceeded that of children without congenital anomalies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Turner Syndrome
Type of study:
Etiology_studies
/
Observational_studies
Limits:
Child
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Birth Defects Res
Year:
2023
Document type:
Article