Oxidative Cleavage and Fluoromethylthiolation of CâC Bonds: A General Route toward Mono-, Di-, and Trifluoromethylthioesters from Alkenes.
Org Lett
; 25(32): 5984-5988, 2023 Aug 18.
Article
in En
| MEDLINE
| ID: mdl-37548642
ABSTRACT
A novel oxidative cleavage and fluoromethylthiolation reaction of CâC bonds has been developed that represents the first and general method for the preparation of mono-, di-, and trifluoromethylthioesters from alkenes. The protocol features excellent product selectivity and substrate suitability. Various observations suggested that the protocol proceeded via a two-step radical process and that aldehyde was the key intermediate. What's more meaningful is that this route provides a new direction for converting alkenes into higher-value-added carbonyl-containing chemicals.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Year:
2023
Document type:
Article