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Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease.
Gbinigie, Oghenekome; Ogburn, Emma; Allen, Julie; Dorward, Jienchi; Dobson, Melissa; Madden, Tracie-Ann; Yu, Ly-Mee; Lowe, David M; Rahman, Najib; Petrou, Stavros; Richards, Duncan; Hood, Kerenza; Patel, Mahendra; Saville, Benjamin R; Marion, Joe; Holmes, Jane; Png, May Ee; Hayward, Gail; Lown, Mark; Harris, Victoria; Jani, Bhautesh; Hart, Nigel; Khoo, Saye; Rutter, Heather; Chalk, Jem; Standing, Joseph F; Breuer, Judith; Lavallee, Layla; Hadley, Elizabeth; Cureton, Lucy; Benysek, Magdalena; Andersson, Monique I; Francis, Nick; Thomas, Nicholas P B; Evans, Philip; van Hecke, Oliver; Koshkouei, Mona; Coates, Maria; Barrett, Sarah; Bateman, Clare; Davies, Jennifer; Raymundo-Wood, Ivy; Ustianowski, Andrew; Nguyen-Van-Tam, Jonathan; Carson-Stevens, Andrew; Hobbs, Richard; Little, Paul; Butler, Christopher C.
Affiliation
  • Gbinigie O; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Ogburn E; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Allen J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Dorward J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Dobson M; Centre for the Aids Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.
  • Madden TA; Nuffield Department of Medicine, Oxford Respiratory Trials Unit, Oxford, UK.
  • Yu LM; Centre for Trials Research, Cardiff University, Cardiff, UK.
  • Lowe DM; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Rahman N; University College London, Institute of Immunity and Transplantation, London, UK.
  • Petrou S; Nuffield Department of Medicine, Oxford Respiratory Trials Unit, Oxford, UK.
  • Richards D; NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Hood K; Chinese Academy of Medicine Oxford Institute, University of Oxford, Oxford, UK.
  • Patel M; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Saville BR; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
  • Marion J; Centre for Trials Research, Cardiff University, Cardiff, UK.
  • Holmes J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Png ME; Berry Consultants, Austin, Texas, USA.
  • Hayward G; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Lown M; Berry Consultants, Austin, Texas, USA.
  • Harris V; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Jani B; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Hart N; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Khoo S; Primary Care Research Centre, University of Southampton, Southampton, UK.
  • Rutter H; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Chalk J; General Practice and Primary Care, School of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK.
  • Standing JF; School of Medicine, Dentistry and Biomedical Sciences - Centre for Public Health, Queen's University Belfast, Belfast, UK.
  • Breuer J; Department of Pharmacology, University of Liverpool, Liverpool, UK.
  • Lavallee L; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Hadley E; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Cureton L; Infection Inflammation and Immunology, UCL Great Ormond Street Institute of Child Health Population Policy and Practice, London, UK.
  • Benysek M; Department of Pharmacy, Great Ormond Street Hospital for Children, London, UK.
  • Andersson MI; Infection Inflammation and Immunology, UCL Great Ormond Street Institute of Child Health Population Policy and Practice, London, UK.
  • Francis N; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Thomas NPB; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Evans P; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • van Hecke O; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Koshkouei M; Department of Microbiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Coates M; Primary Care Research Centre, University of Southampton, Southampton, UK.
  • Barrett S; Windrush Medical Practice, Witney, UK.
  • Bateman C; Thames Valley and South Midlands Clinical Research Network, National Institute for Health and Care Research, Oxford, UK.
  • Davies J; Royal College of General Practitioners, London, UK.
  • Raymundo-Wood I; Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
  • Ustianowski A; National Institute for Health Research Clinical Research Network, London, UK.
  • Nguyen-Van-Tam J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Carson-Stevens A; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Hobbs R; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Little P; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Butler CC; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
BMJ Open ; 13(8): e069176, 2023 08 07.
Article in En | MEDLINE | ID: mdl-37550022
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 / 2_ODS3 / 4_TD / 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: COVID-19 Type of study: Clinical_trials / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Ethics Limits: Aged / Humans / Middle aged Language: En Journal: BMJ Open Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 / 2_ODS3 / 4_TD / 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: COVID-19 Type of study: Clinical_trials / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Ethics Limits: Aged / Humans / Middle aged Language: En Journal: BMJ Open Year: 2023 Document type: Article