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A Nanobody-Bioorthogonal Catalyst Conjugate Triggers Spatially Confined Prodrug Activation for Combinational Chemo-immunotherapy.
Zhao, Zhennan; Wang, Xinyu; Wang, Jinhui; Li, Yiyi; Lin, Wenkai; Lu, Kai; Chen, Jun; Xia, Wei; Mao, Zong-Wan.
Affiliation
  • Zhao Z; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, IGCME, Sun Yat-sen University, Guangzhou 510275, China.
  • Wang X; Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
  • Wang J; Guangdong Engineering & Technology Research Center for Disease-Model Animals, Laboratory Animal Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
  • Li Y; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, IGCME, Sun Yat-sen University, Guangzhou 510275, China.
  • Lin W; Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
  • Lu K; Guangdong Engineering & Technology Research Center for Disease-Model Animals, Laboratory Animal Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
  • Chen J; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, IGCME, Sun Yat-sen University, Guangzhou 510275, China.
  • Xia W; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, IGCME, Sun Yat-sen University, Guangzhou 510275, China.
  • Mao ZW; Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
J Med Chem ; 66(17): 11951-11964, 2023 09 14.
Article in En | MEDLINE | ID: mdl-37590921
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs Limits: Animals / Humans Language: En Journal: J Med Chem Year: 2023 Document type: Article
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs Limits: Animals / Humans Language: En Journal: J Med Chem Year: 2023 Document type: Article