The role of cepharanthine as an anti-atherosclerotic agent in rats.
Pak J Pharm Sci
; 36(4): 1073-1077, 2023 Jul.
Article
in En
| MEDLINE
| ID: mdl-37599480
ABSTRACT
This investigation assessed the potential of cepharanthine (CEP), a compound from Stephania cepharantha Hayata, in mitigating atherosclerosis in a hyperlipidemic rat model. Using Wistar rats, four distinct diet and drug treatment groups were established a high-fat high sucrose diet (HFHS), HFHS supplemented with intraperitoneal cepharanthine (HFHS-C) or oral atorvastatin (HFHS-A) from the 8th week, and a normal-fat diet (NFD). The study aimed to evaluate diet and drug impact on aortic histopathological changes over 16 weeks. Our results revealed significant atherosclerosis prevention in the aorta of the HFHS-C group, marked by preserved endothelial integrity, absence of inflammation, and lack of atherosclerotic plaques. Additionally, CEP demonstrated a crucial role in preventing the emergence of cholesterol clefts and foamy macrophages. These findings suggest that CEP effectively curbs atherosclerosis progression in hyperlipidemic rats, reducing arterial fat deposition and offering a potential natural preventative strategy against this disease.
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Collection:
01-internacional
Health context:
1_ASSA2030
Database:
MEDLINE
Main subject:
Benzylisoquinolines
/
Atherosclerosis
/
Plaque, Atherosclerotic
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Pak J Pharm Sci
Year:
2023
Document type:
Article