Novel scoring tool of hypoxemic respiratory failure and pulmonary hypertension for defining severity of persistent pulmonary hypertension of newborn.
J Perinatol
; 43(10): 1281-1287, 2023 10.
Article
in En
| MEDLINE
| ID: mdl-37626160
ABSTRACT
OBJECTIVE:
To obtain preliminary validity data for a hypoxemic respiratory failure/pulmonary hypertension (HRF/PH) score for classifying persistent pulmonary hypertension of the newborn (PPHN). STUDYDESIGN:
Retrospective chart review of 100 consecutive neonates admitted to a Children's hospital from 2016-2021 with PPHN, gestational age ≥34 weeks, and echocardiograms in the first week. We assessed the correlation between HRF/PH score and short-term outcomes using linear and logistic regressions.RESULTS:
HRF/PH scores ranged 2-12 (mean 8.5), and were classified mild (0-5), moderate (6-10), and severe (11-15), with 6%, 77% and 17% infants in respective categories. HRF/PH score category correlated with invasive ventilation, nitric oxide, high frequency ventilation, vasoactive infusions, extracorporeal life support and death. HRF/PH score category did not correlate with duration of support or length of stay.CONCLUSION:
The HRF/PH score offers a promising representation of disease severity for PPHN. The tool requires further validation in prospective studies and evaluation for long-term outcomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Persistent Fetal Circulation Syndrome
/
Respiratory Insufficiency
/
Hypertension, Pulmonary
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
Limits:
Child
/
Humans
/
Infant
/
Newborn
Language:
En
Journal:
J Perinatol
Year:
2023
Document type:
Article