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P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate.
Zhang, Songya; Zhang, Lin; Greule, Anja; Tailhades, Julien; Marschall, Edward; Prasongpholchai, Panward; Leng, Daniel J; Zhang, Jingfan; Zhu, Jing; Kaczmarski, Joe A; Schittenhelm, Ralf B; Einsle, Oliver; Jackson, Colin J; Alberti, Fabrizio; Bechthold, Andreas; Zhang, Youming; Tosin, Manuela; Si, Tong; Cryle, Max J.
Affiliation
  • Zhang S; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
  • Zhang L; Institut für Biochemie, Albert-Ludwigs-Universität Freiburg, Freiburg 79104, Germany.
  • Greule A; Department of Biochemistry and Molecular Biology, the Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.
  • Tailhades J; Department of Biochemistry and Molecular Biology, the Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.
  • Marschall E; EMBL Australia, Monash University, Clayton 3800, VIC, Australia.
  • Prasongpholchai P; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton 3800, VIC, Australia.
  • Leng DJ; Department of Biochemistry and Molecular Biology, the Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.
  • Zhang J; EMBL Australia, Monash University, Clayton 3800, VIC, Australia.
  • Zhu J; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton 3800, VIC, Australia.
  • Kaczmarski JA; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
  • Schittenhelm RB; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
  • Einsle O; School of Life Sciences, University of Warwick, Gibbet Hill Campus, Coventry CV4 7AL, UK.
  • Jackson CJ; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
  • Alberti F; Research School of Chemistry, the Australian National University, Acton 2601, ACT, Australia.
  • Bechthold A; Department of Biochemistry and Molecular Biology, the Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, VIC, Australia.
  • Zhang Y; Monash Proteomics and Metabolomics Facility, Monash University, Clayton 3800, VIC, Australia.
  • Tosin M; Institut für Biochemie, Albert-Ludwigs-Universität Freiburg, Freiburg 79104, Germany.
  • Si T; ARC Centre of Excellence for Innovations in Peptide and Protein Science, Clayton 3800, VIC, Australia.
  • Cryle MJ; Research School of Chemistry, the Australian National University, Acton 2601, ACT, Australia.
Acta Pharm Sin B ; 13(8): 3561-3574, 2023 Aug.
Article in En | MEDLINE | ID: mdl-37655329
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Acta Pharm Sin B Year: 2023 Document type: Article
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Acta Pharm Sin B Year: 2023 Document type: Article