A novel, quantitative clot retraction assay to evaluate platelet function.
Platelets
; 34(1): 2254403, 2023 Dec.
Article
in En
| MEDLINE
| ID: mdl-37700390
Platelets are cell fragments in the blood that are necessary for clot formation. They are crucial to preventing excessive bleeding following trauma. To form clots, platelets clump (aggregate) and attach to fibrin protein and cells inside the blood vessels to form strong web-like structures. Platelets also contract to pull the edges of the wound close. Most measurements of platelet function involve aggregation. This paper focuses on platelet contraction. Here, we describe a new assay to measure platelets contraction that is repeatable and reproducible. The assay uses standard and common laboratory equipment and can be performed by most laboratory personnel and has the potential to detect clinical pathologies of clot formation. The assay could be developed for bedside patient care where platelet function could be assessed rapidly and assist in the diagnosis of coagulation and platelet disorders.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Platelet Activation
/
Platelet-Rich Plasma
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Platelets
Year:
2023
Document type:
Article