DISCERN: deep single-cell expression reconstruction for improved cell clustering and cell subtype and state detection.

Hausmann, Fabian; Ergen, Can; Khatri, Robin; Marouf, Mohamed; Hänzelmann, Sonja; Gagliani, Nicola; Huber, Samuel; Machart, Pierre; Bonn, Stefan

Hausmann, Fabian; Ergen, Can; Khatri, Robin; Marouf, Mohamed; Hänzelmann, Sonja; Gagliani, Nicola; Huber, Samuel; Machart, Pierre; Bonn, Stefan.

Affiliation

Hausmann F; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Ergen C; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Khatri R; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Marouf M; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Hänzelmann S; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Gagliani N; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Huber S; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Machart P; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Bonn S; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Genome Biol ; 24(1): 212, 2023 09 20.

Article in En | MEDLINE | ID: mdl-37730638

Subject(s)

COVID-19; Humans; COVID-19/genetics; Algorithms; Cell Cycle; Cell Differentiation; Cluster Analysis

Key words

Auto encoder; Batch effect correction; COVID-19; Cell clustering; Cell type identification; Deep Learning; Expression reconstruction; Imputation; Machine Learning; Probabilistic modeling; RNA sequencing; Reference atlas mapping; Single-cell RNA-seq; T helper cell; Transcription factor analysis; Transfer learning

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Genome Biol Year: 2023 Document type: Article

Fulltext

XML

PubMed Links

Search on Google