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Management of nonfermenting gram-negative infections: a critique of the guidelines.
Bassetti, Matteo; Vena, Antonio; Giacobbe, Daniele Roberto.
Affiliation
  • Bassetti M; Department of Health Sciences (DISSAL), University of Genoa.
  • Vena A; Clinica Malattie Infettive, San Martino Policlinico Hospital - IRCCS for Oncology and Neurosciences, Genoa, Italy.
  • Giacobbe DR; Department of Health Sciences (DISSAL), University of Genoa.
Curr Opin Infect Dis ; 36(6): 609-614, 2023 12 01.
Article in En | MEDLINE | ID: mdl-37769165
PURPOSE OF REVIEW: In the present narrative review, we discuss the characteristics and differences between the Infectious Diseases Society of America (IDSA) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines in terms on their recommendations/suggestions for the treatment of Pseudomonas aeruginosa and Acinetobacter baumannii infections. RECENT FINDINGS: Treatment of severe infections caused by nonfermenting gram-negative bacteria (NF-GNB) is posing both novel hopes and novel challenges to physicians worldwide, and both the IDSA and the ESCMID have recently updated/released their guidelines or guidance documents, based on different philosophies and providing recommendations for the treatment of NF-GNB infections. In order to correctly exploit recent advances in the treatment of such infections, IDSA and ESCMID approaches should be viewed as complementary and evolving, and should not preclude further revision based on accumulating evidence on the use of novel ß-lactams and ß-lactam/ß-lactamase inhibitor combinations. SUMMARY: A joint consideration of both philosophies should leave the door opened for the wise use of novel agents, ultimately building precious experience on their use that could favorably influence future guidelines revisions.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acinetobacter Infections / Communicable Diseases Type of study: Guideline Limits: Humans Language: En Journal: Curr Opin Infect Dis Year: 2023 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acinetobacter Infections / Communicable Diseases Type of study: Guideline Limits: Humans Language: En Journal: Curr Opin Infect Dis Year: 2023 Document type: Article