Fatty Acids and their Proteins in Adipose Tissue Inflammation.
Cell Biochem Biophys
; 82(1): 35-51, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-37794302
ABSTRACT
Chronic low-grade adipose tissue inflammation is associated with metabolic disorders. Inflammation results from the intertwined cross-talks of pro-inflammatory and anti-inflammatory pathways in the immune response of adipose tissue. In addition, adipose FABP4 levels and lipid droplet proteins are involved in systemic and tissue inflammation. Dysregulated adipocytes help infiltrate immune cells derived from bone marrow responsible for producing cytokines and chemokines. When adipose tissue expands in excess, adipocyte exhibits increased secretion of adipokines and is implicated in metabolic disturbances due to the release of free fatty acids. This review presents an emerging concept in adipose tissue fat metabolism, fatty acid handling and binding proteins, and lipid droplet proteins and their involvement in inflammatory disorders.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adipose Tissue
/
Fatty Acids
Limits:
Humans
Language:
En
Journal:
Cell Biochem Biophys
Year:
2024
Document type:
Article