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Detection and tracking of cytoplasmic G-quadruplexes in live cells.
Rao, Lu-Si; Hao, Liang; Liu, Liu-Yi; Zeng, You-Liang; Liang, Bing-Bing; Liu, Wenting; Mao, Zong-Wan.
Affiliation
  • Rao LS; Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, IGCME, Sun Yat-Sen University, Guangzhou 510275, China. liuwenting@mail.sysu.edu.cn.
  • Hao L; Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, IGCME, Sun Yat-Sen University, Guangzhou 510275, China. liuwenting@mail.sysu.edu.cn.
  • Liu LY; Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, IGCME, Sun Yat-Sen University, Guangzhou 510275, China. liuwenting@mail.sysu.edu.cn.
  • Zeng YL; Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, IGCME, Sun Yat-Sen University, Guangzhou 510275, China. liuwenting@mail.sysu.edu.cn.
  • Liang BB; Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, IGCME, Sun Yat-Sen University, Guangzhou 510275, China. liuwenting@mail.sysu.edu.cn.
  • Liu W; Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, IGCME, Sun Yat-Sen University, Guangzhou 510275, China. liuwenting@mail.sysu.edu.cn.
  • Mao ZW; Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, IGCME, Sun Yat-Sen University, Guangzhou 510275, China. liuwenting@mail.sysu.edu.cn.
Chem Commun (Camb) ; 59(89): 13348-13351, 2023 Nov 07.
Article in En | MEDLINE | ID: mdl-37872783
ABSTRACT
A TTPP probe was developed to distinguish G-quadruplexes (G4s) from other nucleic acid topologies through longer fluorescence lifetimes and higher quantum yields. In fluorescence lifetime imaging microscopy, TTPP enabled the visualization of cytoplasmic G4s in live cells, and showed the potential to detect cell apoptosis and ferroptosis by tracking cytoplasmic G4s.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nucleic Acids / G-Quadruplexes Language: En Journal: Chem Commun (Camb) Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nucleic Acids / G-Quadruplexes Language: En Journal: Chem Commun (Camb) Year: 2023 Document type: Article