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Antifungal and antibiofilm activities of chromones against nine Candida species.
Lee, Jin-Hyung; Kim, Yong-Guy; Kim, Yeseul; Lee, Jintae.
Affiliation
  • Lee J-H; School of Chemical Engineering, Yeungnam University , Gyeongsan, South Korea.
  • Kim Y-G; School of Chemical Engineering, Yeungnam University , Gyeongsan, South Korea.
  • Kim Y; School of Chemical Engineering, Yeungnam University , Gyeongsan, South Korea.
  • Lee J; School of Chemical Engineering, Yeungnam University , Gyeongsan, South Korea.
Microbiol Spectr ; 11(6): e0173723, 2023 Dec 12.
Article in En | MEDLINE | ID: mdl-37874140
ABSTRACT
IMPORTANCE The persistence of Candida infections is due to its ability to form biofilms that enable it to resist antifungals and host immune systems. Hence, inhibitions of the biofilm formation and virulence characteristics of Candida sp. provide potential means of addressing these infections. Among various chromone derivatives tested, four chromone-3-carbonitriles showed antifungal, antibiofilm, and antivirulence activities against several Candida species. Their mode of action has been partially revealed, and their toxicity is reported here using nematode and plant models.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Candidiasis / Antifungal Agents Language: En Journal: Microbiol Spectr Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Candidiasis / Antifungal Agents Language: En Journal: Microbiol Spectr Year: 2023 Document type: Article