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Differential Impact of Obesity on the Risk of Diabetes Development in Two Age Groups: Analysis from the National Health Screening Program.
Yoo, Tae Kyung; Han, Kyung-Do; Kim, Yang-Hyun; Nam, Ga Eun; Park, Sang Hyun; Rhee, Eun-Jung; Lee, Won-Young.
Affiliation
  • Yoo TK; Department of Medicine, MetroWest Medical Center, Framingham, MA, USA.
  • Han KD; Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea.
  • Kim YH; Department of Family Medicine, Korea University College of Medicine, Seoul, Korea.
  • Nam GE; Department of Family Medicine, Korea University College of Medicine, Seoul, Korea.
  • Park SH; Department of Biomedicine & Health Science, The Catholic University of Korea, Seoul, Korea.
  • Rhee EJ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Lee WY; Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Diabetes Metab J ; 47(6): 846-858, 2023 11.
Article in En | MEDLINE | ID: mdl-37915188
ABSTRACT
BACKGRUOUND The effect of obesity on the development of type 2 diabetes mellitus (DM) in different age groups remains unclear. We assessed the impact of obesity on the development of DM for two age groups (40-year-old, middle age; 66-year-old, older adults) in the Korean population.

METHODS:

We analyzed Korean National Health Insurance Service data of 4,145,321 Korean adults with 40- and 66-year-old age without DM, between 2009 and 2014. Participants were followed up until 2017 or until the diagnosis of DM. We assessed the risk of DM based on the body mass index and waist circumference of the participants. Multiple confounding factors were adjusted.

RESULTS:

The median follow-up duration was 5.6 years. The association of general and abdominal obesity with the risk of DM development was stronger in the 40-year-old group (general obesity hazard ratio [HR], 3.566, 95% confidence interval [CI], 3.512 to 3.622; abdominal obesity HR, 3.231; 95% CI, 3.184 to 3.278) than in the 66-year-old group (general obesity HR, 1.739; 95% CI, 1.719 to 1.759; abdominal obesity HR, 1.799; 95% CI, 1.778 to 1.820). In the 66-year-old group, abdominal obesity had a stronger association with the development of DM as compared to general obesity. In the 40-year-old group, general obesity had a stronger association with the risk of DM development than abdominal obesity.

CONCLUSION:

The influence of general and abdominal obesity on the development of DM differed according to age. In older adults, abdominal obesity had a stronger association with DM development than general obesity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 Limits: Adult / Aged / Humans / Middle aged Language: En Journal: Diabetes Metab J Year: 2023 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 Limits: Adult / Aged / Humans / Middle aged Language: En Journal: Diabetes Metab J Year: 2023 Document type: Article