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Genome-driven discovery of new serrawettin W2 analogues from Serratia fonticola DSM 4576.
Qiu, Haolin; Xiao, Yang; Shen, Ling; Han, Tao; He, Qiang; Li, Aiying; Zhang, Peng; Cai, Xiaofeng.
Affiliation
  • Qiu H; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China. caixiaofeng@hust.edu.cn.
  • Xiao Y; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China. caixiaofeng@hust.edu.cn.
  • Shen L; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China. caixiaofeng@hust.edu.cn.
  • Han T; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China. caixiaofeng@hust.edu.cn.
  • He Q; Xianning Public Inspection Center of Hubei Province, Xianning 437000, P. R. China.
  • Li A; Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, P.R. China.
  • Zhang P; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China. caixiaofeng@hust.edu.cn.
  • Cai X; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China. caixiaofeng@hust.edu.cn.
Org Biomol Chem ; 21(45): 9029-9036, 2023 11 22.
Article in En | MEDLINE | ID: mdl-37930431
ABSTRACT
By expressing a multimodular NRPS gene sefA from Serratia fonticola DSM 4576 in E. coli, four new serrawettin W2 analogues, namely sefopeptides A-D (1-4), were isolated and structurally characterized and their biosynthesis was proposed. A bioactivity assay showed that sefopeptide C (3) exhibits moderate cytotoxic activity against acute promyelocytic leukemia NB4 cells.
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Leukemia, Promyelocytic, Acute / Escherichia coli Limits: Humans Language: En Journal: Org Biomol Chem Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Leukemia, Promyelocytic, Acute / Escherichia coli Limits: Humans Language: En Journal: Org Biomol Chem Year: 2023 Document type: Article