Genome-driven discovery of new serrawettin W2 analogues from Serratia fonticola DSM 4576.
Org Biomol Chem
; 21(45): 9029-9036, 2023 11 22.
Article
in En
| MEDLINE
| ID: mdl-37930431
ABSTRACT
By expressing a multimodular NRPS gene sefA from Serratia fonticola DSM 4576 in E. coli, four new serrawettin W2 analogues, namely sefopeptides A-D (1-4), were isolated and structurally characterized and their biosynthesis was proposed. A bioactivity assay showed that sefopeptide C (3) exhibits moderate cytotoxic activity against acute promyelocytic leukemia NB4 cells.
Full text:
1
Collection:
01-internacional
Health context:
3_ND
Database:
MEDLINE
Main subject:
Leukemia, Promyelocytic, Acute
/
Escherichia coli
Limits:
Humans
Language:
En
Journal:
Org Biomol Chem
Year:
2023
Document type:
Article