At least seven ribosomal proteins are involved in the control of translational accuracy in a eukaryotic organism.
J Mol Biol
; 190(2): 167-75, 1986 Jul 20.
Article
in En
| MEDLINE
| ID: mdl-3795267
ABSTRACT
In the filamentous fungus Podospora anserina, ribosomal proteins of 60 mutants impaired in the control of translational fidelity have been submitted to electrophoretic analysis. The "four corners" system combining four different two-dimensional polyacrylamide gel electrophoretic systems has been used. An altered electrophoretic pattern has been observed for 12 mutants. In mutants su3, su12 and su11 (decreased translational fidelity), proteins S1, S7 and S8, respectively, are altered. For AS mutants (increased translational fidelity), proteins S9, S12 and S19, respectively, are altered in AS9, AS1 and AS6 mutants, and protein S29 is lacking in AS3 mutants. The data suggest that five of these genes (at least) are the structural genes for the relevant proteins (su3S1, su12S7, AS1S12, AS6S19, AS9S9), while the AS3 gene may code for a modifying enzyme.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ribosomal Proteins
/
Protein Biosynthesis
/
Fungi
Language:
En
Journal:
J Mol Biol
Year:
1986
Document type:
Article