Association of phenotypic frailty and frailty index with type 2 diabetes and dyslipidemia in middle-aged and elderly Chinese: A longitudinal cohort study.
Arch Gerontol Geriatr
; 119: 105311, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38101111
ABSTRACT
PURPOSE:
Frailty, type 2 diabetes (T2D) and dyslipidemia are highly prevalent in middle-aged and elderly populations. However, evidence on the longitudinal association of frailty with T2D and dyslipidemia is limited. The aim of our study was to explore the cross-sectional and longitudinal effects of frailty levels on T2D and dyslipidemia in combination with phenotypic frailty and frailty index (FI). MATERIALS ANDMETHODS:
Multivariate logistic regression model was used to explore the association of frailty status with T2D and dyslipidemia. Area under curve (AUC) of the receiver operating characteristic curve (ROC) to estimate the predictive values of phenotypic frailty and frailty index for T2D and dyslipidemia. In addition, depressive symptom was used as a mediating variable to examine whether it mediates the association between frailty and T2D or dyslipidemia.RESULTS:
10,203 and 9587 participants were chosen for the longitudinal association analysis of frailty with T2D and dyslipidemia. Frailty was associated with T2D (phenotypic frailty OR=1.50, 95 %CI=1.03, 2.17; FI OR=1.17, 95 %CI=1.08, 1.26) and dyslipidemia (phenotypic frailty OR=1.56, 95 %CI=1.16, 2.10; FI OR=1.17, 95 %CI=1.10, 1.25). Phenotypic frailty and frailty index significantly improved the risk discrimination of T2D and dyslipidemia (p<0.05). Depressive symptoms played a mediating role in the association between frailty and long-term T2D or dyslipidemia (p<0.05).CONCLUSION:
Frailty had adverse effects on type 2 diabetes and dyslipidemia, with depressive symptoms acting as the mediator.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 2
/
Dyslipidemias
/
Frailty
Limits:
Aged
/
Humans
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Arch Gerontol Geriatr
Year:
2024
Document type:
Article