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A Neutral Flavin-Triphenylamine Probe for Mitochondrial Bioimaging under Different Microenvironments.
Agrawal, Harsha Gopal; Giri, Pravin Shankar; Meena, Poonam; Rath, Subha Narayan; Mishra, Ashutosh Kumar.
Affiliation
  • Agrawal HG; Department of Chemistry, Indian Institute of Technology, Sangareddy, Hyderabad 502285, Telangana, India.
  • Giri PS; Department of Biomedical Engineering, Indian Institute of Technology, Sangareddy, Hyderabad502285, Telangana, India.
  • Meena P; Department of Chemistry, Indian Institute of Technology, Sangareddy, Hyderabad 502285, Telangana, India.
  • Rath SN; Department of Biomedical Engineering, Indian Institute of Technology, Sangareddy, Hyderabad502285, Telangana, India.
  • Mishra AK; Department of Chemistry, Indian Institute of Technology, Sangareddy, Hyderabad 502285, Telangana, India.
ACS Med Chem Lett ; 14(12): 1857-1862, 2023 Dec 14.
Article in En | MEDLINE | ID: mdl-38116415
ABSTRACT
A bioinspired design built around a neutral flavin-triphenylamine core has been investigated for selective mitochondrial bioimaging capabilities in different microenvironments. Significant advantages with respect to long-term tracking, faster internalization, penetrability within the spheroid structures, and strong emission signal under induced hypoxia conditions have been observed, which could offer an alternative to the existing mitotrackers for hypoxia-related biological events.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Med Chem Lett Year: 2023 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Med Chem Lett Year: 2023 Document type: Article