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Umbrella review and Delphi study on modifiable factors for dementia risk reduction.
Rosenau, Colin; Köhler, Sebastian; Soons, Lion M; Anstey, Kaarin J; Brayne, Carol; Brodaty, Henry; Engedal, Knut; Farina, Francesca R; Ganguli, Mary; Livingston, Gill; Lyketsos, Constantine G; Mangialasche, Francesca; Middleton, Laura E; Rikkert, Marcel G M Olde; Peters, Ruth; Sachdev, Perminder S; Scarmeas, Nikolaos; Salbaek, Geir; van Boxtel, Martin P J; Deckers, Kay.
Affiliation
  • Rosenau C; Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
  • Köhler S; Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
  • Soons LM; Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
  • Anstey KJ; School of Psychology, University of New South Wales, Kensington, New South Wales, Australia.
  • Brayne C; Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia.
  • Brodaty H; UNSW Ageing Futures Institute, Kensington, New South Wales, Australia.
  • Engedal K; Cambridge Public Health, University of Cambridge, Cambridge, UK.
  • Farina FR; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
  • Ganguli M; Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
  • Livingston G; Feinberg School of Medicine, Department of Medical Social Sciences, Northwestern University, Chicago, Illinois, USA.
  • Lyketsos CG; Departments of Psychiatry, Neurology, and Epidemiology, School of Medicine and School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Mangialasche F; Division of Psychiatry, University College London, London, UK.
  • Middleton LE; Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease, Johns Hopkins Bayview, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Rikkert MGMO; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
  • Peters R; Theme Inflammation and Aging, Medical Unit Aging, Karolinska University Hospital, Stockholm, Sweden.
  • Sachdev PS; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
  • Scarmeas N; Schlegel-UW Research Institute for Aging, Waterloo, Ontario, Canada.
  • Salbaek G; Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
  • van Boxtel MPJ; Radboudumc Alzheimer Center, Donders Center of Medical Neurosciences, Nijmegen, the Netherlands.
  • Deckers K; UNSW Ageing Futures Institute, Kensington, New South Wales, Australia.
Alzheimers Dement ; 20(3): 2223-2239, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38159267
ABSTRACT
A 2013 systematic review and Delphi consensus study identified 12 modifiable risk and protective factors for dementia, which were subsequently merged into the "LIfestyle for BRAin health" (LIBRA) score. We systematically evaluated whether LIBRA requires revision based on new evidence. To identify modifiable risk and protective factors suitable for dementia risk reduction, we combined an umbrella review of systematic reviews and meta-analyses with a two-round Delphi consensus study. The review of 608 unique primary studies and opinions of 18 experts prioritized six modifiable factors hearing impairment, social contact, sleep, life course inequalities, atrial fibrillation, and psychological stress. Based on expert ranking, hearing impairment, social contact, and sleep were considered the most suitable candidates for inclusion in updated dementia risk scores. As such, the current study shows that dementia risk scores need systematic updates based on emerging evidence. Future studies will validate the updated LIBRA score in different cohorts. HIGHLIGHTS An umbrella review was combined with opinions of 18 dementia experts. Various candidate targets for dementia risk reduction were identified. Experts prioritized hearing impairment, social contact, and sleep. Re-assessment of dementia risk scores is encouraged. Future work should evaluate the predictive validity of updated risk scores.
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Delphi Technique / Dementia / Risk Reduction Behavior Type of study: Systematic_reviews Limits: Humans Language: En Journal: Alzheimers Dement Year: 2024 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Delphi Technique / Dementia / Risk Reduction Behavior Type of study: Systematic_reviews Limits: Humans Language: En Journal: Alzheimers Dement Year: 2024 Document type: Article