Novel Insights into Prokineticin 1 Role in Pregnancy-related Diseases.
Int J Med Sci
; 21(1): 27-36, 2024.
Article
in En
| MEDLINE
| ID: mdl-38164347
ABSTRACT
Prokineticin 1 (PROK1) is a secreted protein involved in a range of physiological activities such as cell proliferation, migration, angiogenesis, and neuronal cell proliferation. Emerging evidences show that PROK1/PROK receptors (PROKRs) are expressed by trophoblasts, and decidual stroma cells at the maternal-fetal interface. PROK1 plays a critical role in successful pregnancy establishment by regulating the decidualization, implantation and placental development. Dysregulation of prokineticin signaling has been described in certain pathological states associated with pregnancy, including pre-eclampsia, recurrent miscarriage and fetal growth restriction. In this review, the expression and pleiotropic roles of PROK1 under physiological and pathological pregnancy conditions are discussed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pre-Eclampsia
/
Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
/
Gastrointestinal Hormones
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Int J Med Sci
Year:
2024
Document type:
Article