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Relation of prenatal and postnatal PM2.5 exposure with cognitive and motor function among preschool-aged children.
Whitworth, Kristina W; Rector-Houze, Alison M; Chen, Wei-Jen; Ibarluzea, Jesus; Swartz, Michael; Symanski, Elaine; Iniguez, Carmen; Lertxundi, Aitana; Valentin, Antonia; González-Safont, Llucia; Vrijheid, Martine; Guxens, Monica.
Affiliation
  • Whitworth KW; Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA; Center for Precision Environmental Health, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA. Electronic address: Kristina.Whitworth@bcm.edu
  • Rector-Houze AM; Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA; Department of Biostatistics and Data Science, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, 1200 Pressler St.,
  • Chen WJ; Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
  • Ibarluzea J; Spanish Consortium for Research and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain; Environmental Epidemiology and Child Development, Biodonostia Health Research Institute, Paseo Dr. Begiristain s/n, 20014, Donostia-San Sebastian, Spain; Min
  • Swartz M; Department of Biostatistics and Data Science, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, 1200 Pressler St., Houston, TX, 77030, USA.
  • Symanski E; Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA; Center for Precision Environmental Health, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
  • Iniguez C; Spanish Consortium for Research and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain; Department of Statistics and Operational Research, Universitat de València, Calle Dr Moliner, 50, 46100, València, Spain; Epidemiology and Environmental Heal
  • Lertxundi A; Spanish Consortium for Research and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain; Environmental Epidemiology and Child Development, Biodonostia Health Research Institute, Paseo Dr. Begiristain s/n, 20014, Donostia-San Sebastian, Spain; Dep
  • Valentin A; Barcelona Institute of Global Health (ISGlobal), C/del Dr. Aiguader, 88, 08003, Barcelona, Spain.
  • González-Safont L; Spanish Consortium for Research and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain; Epidemiology and Environmental Health Joint Research Unit, The Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), U
  • Vrijheid M; Spanish Consortium for Research and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain; Barcelona Institute of Global Health (ISGlobal), C/del Dr. Aiguader, 88, 08003, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Placa de la Merce, 12, 0800
  • Guxens M; Spanish Consortium for Research and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain; Barcelona Institute of Global Health (ISGlobal), C/del Dr. Aiguader, 88, 08003, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Placa de la Merce, 12, 0800
Int J Hyg Environ Health ; 256: 114317, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38171265
ABSTRACT
The literature informing susceptible periods of exposure on children's neurodevelopment is limited. We evaluated the impacts of pre- and postnatal fine particulate matter (PM2.5) exposure on children's cognitive and motor function among 1303 mother-child pairs in the Spanish INMA (Environment and Childhood) Study. Random forest models with temporal back extrapolation were used to estimate daily residential PM2.5 exposures that we averaged across 1-week lags during the prenatal period and 4-week lags during the postnatal period. The McCarthy Scales of Children's Abilities (MSCA) were administered around 5 years to assess general cognitive index (GCI) and several subscales (verbal, perceptual-performance, memory, fine motor, gross motor). We applied distributed lag nonlinear models within the Bayesian hierarchical framework to explore periods of susceptibility to PM2.5 on each MSCA outcome. Effect estimates were calculated per 5 µg/m3 increase in PM2.5 and aggregated across adjacent statistically significant lags using cumulative ß (ßcum) and 95% Credible Intervals (95%CrI). We evaluated interactions between PM2.5 with fetal growth and child sex. We did not observe associations of PM2.5 exposure with lower GCI scores. We found a period of susceptibility to PM2.5 on fine motor scores in gestational weeks 1-9 (ßcum = -2.55, 95%CrI = -3.53,-1.56) and on gross motor scores in weeks 7-17 (ßcum = -2.27,95%CrI = -3.43,-1.11) though the individual lags for the latter were only borderline statistically significant. Exposure in gestational week 17 was weakly associated with verbal scores (ßcum = -0.17, 95%CrI = -0.26,-0.09). In the postnatal period (from age 0.5-1.2 years), we observed a window of susceptibility to PM2.5 on lower perceptual-performance (ß = -2.42, 95%CrI = -3.37,-1.46). Unexpected protective associations were observed for several outcomes with exposures in the later postnatal period. We observed no evidence of differences in susceptible periods by fetal growth or child sex. Preschool-aged children's motor function may be particularly susceptible to PM2.5 exposures experienced in utero whereas the first year of life was identified as a period of susceptibility to PM2.5 for children's perceptual-performance.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prenatal Exposure Delayed Effects / Air Pollutants / Air Pollution Type of study: Prognostic_studies Limits: Child / Child, preschool / Female / Humans / Infant / Pregnancy Language: En Journal: Int J Hyg Environ Health Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prenatal Exposure Delayed Effects / Air Pollutants / Air Pollution Type of study: Prognostic_studies Limits: Child / Child, preschool / Female / Humans / Infant / Pregnancy Language: En Journal: Int J Hyg Environ Health Year: 2024 Document type: Article