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Canthaxanthin Attenuates the Vascular Aging or Endothelial Cell Senescence by Inhibiting Inflammation and Oxidative Stress in Mice.
Wang, Zhefeng; Li, Lilin; Liao, Souqi; Huang, Ren; Jiang, Yibo; Fei, Jia; Cai, Lijun; Zhang, Keda.
Affiliation
  • Wang Z; Clinical Center for Biotherapy, Central Laboratory, Zhongshan Hospital (Xiamen), Fudan University, 361015 Xiamen, Fujian, China.
  • Li L; Department of Cardiology, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), 518020 Shenzhen, Guangdong, China.
  • Liao S; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, 510632 Guangzhou, Guangdong, China.
  • Huang R; Xiamen Clinical Research Center for Cancer Therapy, 361015 Xiamen, Fujian, China.
  • Jiang Y; Department of Chemical Pathology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, 518172 Hong Kong, China.
  • Fei J; Functional Experimental Teaching Center, School of Medicine, Jinan University, 510632 Guangzhou, Guangdong, China.
  • Cai L; Dapeng New District, Education & Health Bureau, 518118 Shenzhen, Guangdong, China.
  • Zhang K; Department of Biomedical Engineering, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), 518020 Shenzhen, Guangdong, China.
Front Biosci (Landmark Ed) ; 28(12): 367, 2023 12 29.
Article in En | MEDLINE | ID: mdl-38179737
ABSTRACT

BACKGROUND:

Vascular endothelial dysfunction is an early phenotype of aging-related vascular dysfunction. Delaying vascular aging and preventing cardiovascular disease are major public health problems that urgently need to be solved. Scientists have studied various drugs to prevent the occurrence and progress of cardiovascular disease, but progress has been slow. Here, the antisenescence and anti-endothelial damage of canthaxanthin (CX, which is an active molecule from food) has been studied.

METHODS:

This study was performed by adding CX to a model of cell senescence and oxidative damage induced by hydrogen peroxide. Cellular senescence markers (e.g., p16, p21, and p53) and oxidative damage markers (e.g., reactive oxygen species, nitric oxide, malondialdehyde, superoxide dismutase) were evaluated by the enzyme-linked immunosorbent assay, laser scanning confocal microscopy, and Western blotting.

RESULTS:

We found that CX downregulated the expression level of senescence-associated molecules, and significantly reduced the oxidative damage of vascular endothelial cells. These observations showed that CX effectively alleviated the senescence of vascular endothelial cells. Furthermore, CX treatment reduced the expression levels of interleukin-6 (IL-6), tumor necrosis factor alpha, and IL-1ß. Finally, in vivo, CX significantly alleviated vascular senescence.

CONCLUSIONS:

The current study shows that CX has potential application value for treating vascular aging or endothelial cell senescence.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Canthaxanthin Type of study: Prognostic_studies Limits: Animals Language: En Journal: Front Biosci (Landmark Ed) Year: 2023 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Canthaxanthin Type of study: Prognostic_studies Limits: Animals Language: En Journal: Front Biosci (Landmark Ed) Year: 2023 Document type: Article