DNA structural changes (photo)induced by tricarbonyl (pterin)rhenium(I) complex.
J Inorg Biochem
; 252: 112471, 2024 03.
Article
in En
| MEDLINE
| ID: mdl-38181612
ABSTRACT
We report on interactions of different types of DNA molecules including double-stranded and plasmid DNA as well as polynucleotides (poly[dGdC]2 and poly[dAdT]2) with fac-[ReI(CO)3(pterin)(H2O)] (or Reptr) complex. The interaction was characterized spectroscopically and changes in the plasmid structure were verified by both electrophoresis and AFM microscopy. For comparative reasons, two others related tricarbonyl rhenium(I) complexes, fac-[(4,4'-bpy)ReI(CO)3(dppz)]+ (or Redppz) and fac-[(CF3SO3)ReI(CO)3(2,2'-bpy)] (or Rebpy) were also studied to further explore the influence of the different co-ligands on the interaction and DNA (photo)damage. Data reported herein suggests that DNA molecules can be structurally modified either by direct interaction with Re(I) complexes in their ground states inducing DNA relaxation, and/or through photoinduced cross-linking processes. The chemical nature of the co-ligands modulates the extent of the damage observed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pterins
/
Rhenium
Language:
En
Journal:
J Inorg Biochem
Year:
2024
Document type:
Article