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Acute myeloid leukemia-driven IL-3-dependent upregulation of BCL2 in non-malignant hematopoietic stem and progenitor cells increases venetoclax-induced cytopenias.
Fowler-Shorten, Dominic J; Maynard, Rebecca S; Hampton, Katherine; Altera, Annalisa; Markham, Matthew; Ehikioya, Martha; Wojtowicz, Edyta E; Bowles, Kristian M; Rushworth, Stuart A; Hellmich, Charlotte.
Affiliation
  • Fowler-Shorten DJ; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
  • Maynard RS; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
  • Hampton K; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
  • Altera A; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
  • Markham M; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
  • Ehikioya M; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
  • Wojtowicz EE; Earlham Institute, Norwich Research Park, Norwich, NR4 7UH.
  • Bowles KM; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ, United Kingdom; Department of Haematology, Norfolk and Norwich University Hospital NHS Trust, Colney Lane, Norwich, NR4 7UY.
  • Rushworth SA; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ. s.rushworth@uea.ac.uk.
  • Hellmich C; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ, United Kingdom; Department of Haematology, Norfolk and Norwich University Hospital NHS Trust, Colney Lane, Norwich, NR4 7UY. c.hellmich@uea.ac.uk.
Haematologica ; 109(5): 1576-1581, 2024 05 01.
Article in En | MEDLINE | ID: mdl-38186347
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Hematopoietic Stem Cells / Leukemia, Myeloid, Acute / Interleukin-3 / Bridged Bicyclo Compounds, Heterocyclic / Proto-Oncogene Proteins c-bcl-2 Limits: Humans Language: En Journal: Haematologica Year: 2024 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Hematopoietic Stem Cells / Leukemia, Myeloid, Acute / Interleukin-3 / Bridged Bicyclo Compounds, Heterocyclic / Proto-Oncogene Proteins c-bcl-2 Limits: Humans Language: En Journal: Haematologica Year: 2024 Document type: Article